郑楠，女，1980年11月出生 ，内蒙古人 ，博士，副研究员，硕士生导师。

基本信息

 
中文名称  郑楠  出生日期  1980年11月  毕业院校  内蒙古农业大学 

研究方向

风险评估与管理职称中国农业科学院北京畜牧兽医研究所研究员目

人物履历

1998-09-2002-07内蒙古农业大学园艺学学士2002-09-2005-07内蒙古农业大学植物学硕士2006-09-2009-12中国农业大学 营养与食品安全博士2008-01-2009-01英国萨里大学 访问学者2010-02-201208中国农业科学院北京畜牧兽医研究所博士后2012-09-2014-12中国农业科学院北京畜牧兽医研究所助理研究员2015-01-至今 中国农业科学院北京畜牧兽医研究所副研究员2012-12至今 农业部奶产品质量安全风险评估实验室(北京)副主任2015-05至今 农业部奶及奶制品质量监督检验测试中心(北京)常务副主任2016-04至今 中国农垦乳业联盟专家委员会质量安全专家

研究方向

研究方向:风险评估与管理在研课题:公益性行业(农业)科研专项经费项目:生鲜乳质量安全评价技术与生产规程，课题二"生鲜乳危害因子评价技术研究"(201401 - 201812)国家自然科学基金青年科学基金项目:AFM1与OTA、ZEA交互作用对肠屏障功能的损伤及其机理研究(201601 - 201812)国家农产品质量安全风险评估项目:奶产品质量安全风险评估专项(201501 - 201612)

研究成果

检测方法:开发了基于实时定量PCR的新型核酸适配体传感器，实现婴幼儿食品中AFB1的超灵敏检测，检出限可达2.5×10-8mg/kg，是国际上迄今为止检测AFB1最灵敏的方法;系统研究揭示了奶产品中糠氨酸和乳果糖的消长变化规律，构建了评价牛奶品质的特异性模型，研究结果直接用于完成国务院和农业部下达的复原乳鉴定任务，该标准已于2016年4月1日颁布实施。风险评估:以人体"肠屏障"为靶点，发现牛奶中AFM1与OTA、ZEA、α-ZOL等多种霉菌毒素共存时，毒性显著增强，其机理是协同损伤肠细胞间紧密连接蛋白，进而破坏肠道上皮细胞的完整性，揭示了AFM1与其他霉菌毒素共存时，尽管单个都不超标，但是存在健康风险，研究结果为针对霉菌毒素共存这一新的食品安全隐患制定限量标准提供了重要科学依据。

代表论文

王加启，郑楠等. 中国奶产品质量安全研究报告(2015年度).中国农业科学技术出版社. 2016.X.D. Guo, F. Wen, Q.J. Luo, H.W. Wang, H. Wang, S.L. Li,N. Zheng, J.Q. Wang, Development of an ultrasensitive aptasensor for the detection of aflatoxin B1. Biosensors and Bioelectronics, 2014, 56, 340-344.Y.N.Gao, J.Q.Wang, S.L.Li, Y.D.Zhang, N.Zheng.Aflatoxin M1 cytotoxicity against human intestinal Caco-2cells is enhanced in the presence of other mycotoxins. Food and Chemical Toxicology. 2016.H.W. Wang, J.Q. Wang, B.Q. Zheng, S.L. Li, Y.D. Zhang, F.D. Li,N. Zheng. Cytotoxicity induced by ochratoxin A, zearalenone, and α-zearalenol: Effects of individual and combined treatment. Food and Chemical Toxicology, 2014, 71,217-224.Ming Li, Fang Wen, Shengguo Zhao, Pengpeng Wang, Songli Li, Yangdong Zhang, Nan Zheng， Jiaqi Wang. Exploring the Molecular Basis for Binding of Inhibitors by Threonyl-tRNA Synthetase from Brucella abortus: A Virtual Screening Study. International Journal of Molecular Sciences, 2016, 17(7), 1078.H. Tian,N. Zheng, W. Wang, J. Cheng, S. Li, Y. Zhang, J. Wang. Integrated Metabolomics Study of the Milk of Heat-stressed Lactating Dairy Cows. Scientific Report, 2016. (DOI: 10.1038)Y. Yang,N. Zheng, X. Zhao, Y. Zhang, R. Han, L. Ma, S. Zhao, S. Li, T. Guo, J. Wang. Proteomic characterization and comparison of mammalian milk fat globule proteomes by iTRAQ analysis. Journal of Proteomics, 2015, 116, 34-43.Y. Yang,N. Zheng, X. Zhao, Y. Zhang, R. Han, J. Yang, S. Zhao, S. Li, T. Guo, C. Zang, J. Wang. Metabolomic biomarkers identify differences in milk produced by Holstein cows and other minor dairy animals. Journal of Proteomics, 2016, 136, 174-182.L.C. Huang,N. Zheng, B.Q. Zheng, F. Wen, J.B. Cheng, R.W. Han, X.M. Xu, S.L. Li, J.Q. Wang. Simultaneous determination of aflatoxin M1, ochratoxin A, zearalenone and α-zearalenol in milk by UHPLC–MS/MS. Food Chemistry, 2014, 146, 242-249.R.W. Han,N. Zheng, Z.N. Yu, J.Q. Wang, X.M. Xu, X.Y. Qu, S.L. Li, Y.D. Zhang, J.Q. Wang. Simultaneous determination of 38 veterinary antibiotic residues in raw milk by UPLC–MS/MS. Food Chemistry, 2015, 181, 119-126.J. Zhang,N. Zheng, J. Liu, F.D. Li, S.L. Li, J.Q. Wang. Aflatoxin B1 and aflatoxin M1 induced cytotoxicity and DNA damage in differentiated and undifferentiated Caco-2 cells. Food and Chemical Toxicology, 2015, 83, 54-60.N. Zheng, P. Sun, J.Q. Wang, Y.P. Zhen, R.W. Han, X.M. Xu. Occurrence of aflatoxin M1 in UHT milk and pasteurized milk in China market. Food Control, 2013, 29, 198-201.N. Zheng, J.Q. Wang, R.W. Han, Y.P. Zhen, X.M. Xu, P. Sun. Survey of aflatoxin M1 in raw milk in the five provinces of China. Food Additives & Contaminants Part B-Surveillance, 2013, 6, 110-115.N. Zheng, J.Q. Wang, R.W. Han, X.M. Xu, Y.P. Zhen, X.Y. Qu, P. Sun, S.L. Li, Z.N. Yu. Occurrence of Several Main Antibiotic Residues in Raw Milk in Ten Provinces of China，Food Additives & Contaminants Part B-Surveillance, 2012, 6, 84-89.R.W. Han,N. Zheng, J.Q. Wang, Y.P. Zhen, X.M. Xu, S.L. Li. Survey of aflatoxin in dairy cow feed and raw milk in China. Food Control, 2013, 34, 35-39.H. Tian, W. Wang,N. Zheng, J. Cheng, S. Li, Y. Zhang, J. Wang. Identification of diagnostic biomarkers and metabolic pathway shifts of heat-stressed lactating dairy cows. Journal of Proteomics, 2015, 125, 17-28.Y. Yang,N. Zheng, J. Yang, D. Bu, J. Wang, L Ma, P Sun. Animal species milk identification by comparison of two-dimensional gel map profile and mass spectrometry approach. International Dairy Journal, 2014, 35, 15-20.Y.D. Zhang,N. Zheng, R.W. Han, B.Q. Zheng, Z.N. Yu, S.L. Li, S.S. Zheng, J.Q. Wang. Occurrence of tetracyclines, sulfonamides, sulfamethazine and quinolones in pasteurized milk and UHT milk in Chinas market. Food Control, 2014, 36, 238-242.L. Min,N. Zheng, S. Zhao, J. Cheng, Y. Yang, Y Zhang, H Yang, Ji. Wang. Long-term heat stress induces the inflammatory response in dairy cows revealed by plasma proteome analysis. Biochemical and Biophysical Research Communications, 2016, 471, 296-302.

获得奖励

郑楠(2/10).生鲜乳质量安全控制关键技术及应用，河北省人民政府，河北省科学技术奖，一等奖，2014。